Compensatory Pathways Explain Drug Discovery's Low Success Rate
Drug programs fail mostly because alternate biological pathways bypass the target, not because the chemistry fails.
concept
drug-discoverymedicine
Sources
Coursera: *Drug discovery and development* (Introduction to Drug Hunting > Introduction to Drug Hunting, part 1), 0:03
Coursera: *Unmet medical need and key scientific questions* (Introduction to Drug Hunting > Introduction to Drug Hunting, part 1), 1:50
Coursera: *Target-Based Drug Discovery* (Targets, Assays & Screening > Targets, Assays & Screening, part 1), 1:57