Drug pKa and pH Control Oral Absorption Site
A drug's pKa and the GI tract's pH gradient together determine whether it is ionized or neutral at each location, which in turn controls where dissolution and absorption occur.
concept
drug-discoverymedicine
Sources
Coursera: *Physicochemical Properties* (Pre-formulation > Pre-formulation, part 1), 0:02
Coursera: *Physicochemical Properties* (Pre-formulation > Pre-formulation, part 1), 1:53