hERG Inhibition Risks Lethal Cardiac Arrhythmia
Blocking the hERG potassium channel delays cardiac repolarization, prolonging the QT interval and risking torsades de pointes -- a potentially fatal arrhythmia.
concept
drug-discoverymedicine
Sources
Coursera: *Preclinical Safety* (Introduction to Drug Hunting > Introduction to Drug Hunting, part 3), 1:53
Coursera: *Preclinical Studies Supporting Human Clinical Trials* (Preclinical Safety > Preclinical Safety, part 3), 3:49