Hits Require Selectivity and Safety to Become Leads
Potency in a binding assay isn't enough -- hits advance only when selectivity, physicochemical properties, PK viability, and safety margins also pass.
concept
drug-discoverymedicine
Sources
Coursera: *Lead Selection* (Introduction to Drug Hunting > Introduction to Drug Hunting, part 2), 0:03
Coursera: *Lead Selection* (Introduction to Drug Hunting > Introduction to Drug Hunting, part 2), 2:00
Coursera: *Hit Criteria and Characterization* (Lead Selection & Optimization > Lead Selection & Optimization, part 2), 0:02
Coursera: *Hit Criteria and Characterization* (Lead Selection & Optimization > Lead Selection & Optimization, part 2), 2:02