LiPE Favors Low-Lipophilicity Compounds Over Raw Potency
Lipophilic efficiency (LiPE = pIC₅₀ - logD) normalizes potency by lipophilicity, exposing which compounds achieve binding efficiently rather than through brute hydrophobicity.
concept
drug-discoverymedicine
Sources
Coursera: *Composite Parameters in Discovery* (Lead Selection & Optimization > Lead Selection & Optimization, part 2), 0:03
Coursera: *Composite Parameters in Discovery* (Lead Selection & Optimization > Lead Selection & Optimization, part 2), 1:59