Lipophilicity Gains Potency but Costs Solubility and Safety
More lipophilic compounds bind targets more potently but also show lower solubility, faster metabolism, higher toxicity risk, and broader nonspecific protein binding.
concept
drug-discoverymedicine
Sources
Coursera: *Composite Parameters in Discovery* (Lead Selection & Optimization > Lead Selection & Optimization, part 2), 1:59
Coursera: *Optimization of ADME Properties* (Lead Selection & Optimization > Lead Selection & Optimization, part 2), 0:03